In vivo degradation behavior of porous composite scaffolds of poly(lactide-co-glycolide) and nano-hydroxyapatite surface grafted with poly(L-lactide)
writer：Yu-feng Tang, Jian-guo Liu 刘建国, Zong-liang Wang, Yu Wang, Li-guo Cui, Pei-biao Zhang 章培标, Xue-si Che
keywords：Nanocomposite; Surface modification; Absorption; Biomineralization; Biochemical detection
source：期刊
specific source：Chinese Journal of Polymer Science Vol. 32, No. 6, (2014), 805?816
Issue time：2014年
Intramuscular implantation test of 20w showed that porous composite scaffolds of surface grafted g-HAP/PLGA and ungrafted n-HAP/PLGA presented slower degradation and higher mineralization compared to that of pure PLGA. Compared with n-HAP/PLGA, g-HAP/PLGA showed an improved absorption and biomineralization because of its improved distribution of g-HAP nanoparticles in PLGA matrix.
http://link.springer.com/content/pdf/10.1007%2Fs10118-014-1454-5.pdf