writer：[1] Dong Ma, Zong-Hua Liu, Qian-Qian Zheng, Xiao-Yan Zhou, Yi Zhang, Yun-Feng Shi, Jian-Tao Lin, Wei
keywords：star polymer, porphyrin, chemo/photodynamic therapy
source：期刊
specific source：Macromolecular Rapid Communications
Issue time：2013年
A novel star-shaped polymer, porphyrin-poly(L-lysine) dendrons (PP-PLLD), is synthesized by the click reaction between azido-modifi ed porphyrin and propargyl focal point poly(L-lysine) dendrons. Its chemical structure is characterized by 1 H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography (GPC) is analyses etc. Due to its amphiphilic property, the obtained PP-PLLD has a low critical micelle concentration in an aqueous solution, and can load doxorubicin (DOX) with a loading amount of 64 μ g mg ? 1 . By in vitro toxicity assay, PP-PLLD has no dark cytotoxicity but has signifi cant phototoxicity. Moreover, DOX-loaded PP-PLLD shows a higher cytotoxicity under the light condition than PP-PLLD or DOX alone, suggesting PP-PLLD has a potential application in combined photodynamic therapy and chemotherapy.