【Chemical Communications】Facile fabrication of microsphere-polymer brush hierarchically three-dimensional (3d) substrates for immunoassays
作者：Jiao Ma, Shifang Luan*, Jing Jin, Jinghua Yin*, et al.,
关键字：polymer brush, immunoassays
论文来源：期刊
具体来源：Chemical Communications, 2015, 51, 6749-6752
发表时间：2015年
Abstract:
We propose a facile UV strategy to construct a hierarchically three-dimensional (3D) substrate that comprises a polystyrene (PS) microsphere layer on the cycloolefin polymer (COP) substrate and densely packed hydrophilic polymer brushes grafting from this 3D backbone. This hierarchical substrate gives a high antibody loading capacity and 3D manner of analyte capture, therefore enhancing detection signal while reducing background noise.