作者：Ran Yang, Binggang Chen*, Xu Zhang, Zijian Bao, Qiuyan Yan, Shifang Luan* .
关键字：nano-hydroxyapatite, radical ring-opening polymerization
论文来源：期刊
具体来源：ACS Nano
发表时间：2024年

Abstract:

Bone glue with robust adhesion is crucial for treating complicated bone fractures, but it remains a formidable challenge to develop a “true” bone glue with high adhesion strength, degradability, bioactivity, and satisfactory operation time in clinical scenarios. Herein, inspired by the hydroxyapatite and collagen matrix composition of natural bone, we construct a nano-hydroxyapatite (nHAP) reinforced osteogenic backbone-degradable superglue (O-BDSG) by in situ radical ring-opening polymerization. nHAP significantly enhances adhesive cohesion by synergy of acting as non-covalent connectors between polymer chains and increasing the molecular weight of the polymer matrix. Moreover, nHAP endows the glue with bioactivity to promote osteogenesis. The as-prepared glue presented a 9.79 MPa flexural adhesion strength for bone, 4.7 times that of without nHAP, and significantly surpasses commercial cyanoacrylate (0.64 MPa). O-BDSG exhibited degradability with a 51% mass loss after 6 months of implantation. In vivo critical defect and tibia fracture models demonstrated the promoted osteogenesis of O-BDSG, with a new bone volume of 75% and the mechanical function restored to 94% of the native tibia after 8 weeks. The glue can be flexibly adapted to clinical scenarios with a curing time window of about 3 minutes. This work shows promising prospects for clinical application in orthopedic surgery and may inspire the design and development of bone adhesives.