作者：Ran Yang, Fei Chen, Jinshan Guo, Dongfang Zhou, Shifang Luan*，et al.,
关键字：Cartilage repair ，Gene therapy ，Polymeric biomaterials
论文来源：期刊
具体来源：Bioactive Materials
发表时间：2020年

Abstract:

Untreated articular cartilage damage normally results in osteoarthritis and even disability that aects millions of people. However, both the existing surgical treatment and tissue engineering approaches are unable to regenerate the original structures of articular cartilage durably, and new strategies for integrative cartilage repair are needed. Gene therapy provides local production of therapeutic factors, especially guided by biomaterials can minimize the diusion and loss of the genes or gene complexes, achieve accurate spatiotemporally release of gene products, thus provideing long-term treatment for cartilage repair. The widespread application of gene therapy requires the development of safe and ective gene delivery vectors and supportive gene-activated matrices. Among them, polymeric biomaterials are particularly attractive due to their tunable physiochemical properties, as well as excellent adaptive performance. This paper reviews the recent advances in polymeric biomaterial-guided gene delivery for cartilage repair, with an emphasis on the important role of polymeric biomaterials in delivery systems.