writer：Xiaomeng Li, Shifang Luan*, Hengchong Shi, Huawei Yang, Lingjie Song, Jing Jin, Jinghua Yin*, et al.,
keywords：Glycidyl methacrylate-hyaluronic acid (GMHA), UV-induced graft polymerization, Poly (styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS), Platelet adhesion, Cytocompatibility
source：期刊
specific source：Colloids & Surface B, 2013, 102, 210-217
Issue time：2013年

Abstract:

Hyaluronic acid (HA) is an important component of extracellular matrix (ECM) in many tissues, providing a hemocompatible and supportive environment for cell growth. In this study, glycidyl methacrylatehyaluronic acid (GMHA) was first synthesized and verified by proton nuclear magnetic resonance (1H NMR) spectroscopy. GMHA was then grafted to the surface of biomedical elastomer poly (styrene-b-(ethylene-co-butylene)-b-styrene) (SEBS) via an UV-initiated polymerization, monitored by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The further improvement of biocompatibility of the GMHA-modified SEBS films was assessed by platelet adhesion experiments and in vitro response of murine osteoblastic cell line MC-3T3-E1 with the virgin SEBS surface as the reference. It showed that the surface modification with HA strongly resisted platelet adhesion whereas improved cell–substrate interactions.