作者：Song, Yang, Zaifu Lin, Lingqing Kong, Yao Xing, Naibo Lin, Zhisen Zhang, Bing-Hung Chen, and Xiang-Y
关键字：bioimaging, hierarchical structures, silk, upconversion
论文来源：期刊
发表时间：2017年

In biomedical applications, it is very desirable to monitor the in vivo state of implanted devices, i.e., tracking the location, the state, and the interaction between the implanted devices and cell tissues. To achieve this goal, a generic strategy of soft materials meso-functionalization is presented. This is to acquire silk fibroin (SF) materials with added functions, i.e., in vivo bioimaging/sensing. The functionalization is by 3D materials assembly of functional components, lanthanide(Ln)-doped upconversion nanoparticles (UCNPs) on the mesoscopic scale to acquire upconversion fluorescent emission. To implement the meso-functionalization, the surfaces of UCNPs are modified by the hydroxyl groups (-OH) from SiO2 or polyethylene glycol coating layers, which can interact with the carbonyl groups (COO) in SF scaffolds. The functionalized silk scaffolds are further implanted subcutaneously into mice, which allows the silk scaffolds to have fluorescent in vivo bioimaging and other biomedical functions. This material functionalization strategy may lead to the rational design of biomaterials in a more generic way.