writer：Shenghai Li, Haibo Xie, Suobo Zhang*, Yingjie Lin, Jianing Xu, Jungang Cao
keywords：Tetramethylguanidine, Heck reaction, Palladinium, Ligand
source：期刊
specific source：Synlett.
Issue time：2005年

An inexpensive and efficient Pd(OAc)₂/tetramethylguanidine (TMG) or PdCl₂/TMG catalytic system has been developed for the Heck reaction of an olefin with an aryl halide. The TONs were up to 1000000 when iodobenzene was used as the substrate with butyl acrylate as the reactant. In addition, [Pd(TMG)₄]Cl₂(H₂O)₈, an air-stable compound, effectively promoted the Heck reaction, which demonstrated that TMG acted as a ligand in this reaction system.