作者：Dongying Xu, Mouming Zhao, Jiaoyan Ren, Guangji Li, Zhengfu Liao
关键字：4-aminosalicylic acid，Interaction，KGM
论文来源：期刊
具体来源：http://dx.doi.org/10.1016/j.foodres.2010.06.011；Food Research International
发表时间：2010年

Wide angle X-ray diffraction patterns, differential scanning calorimetry, UV–vis spectra and steady-state fluorescence spectroscopy were used to examine the interactions of konjac glucomannan (KGM) and 4-aminosalicylic acid (4-ASA) in aqueous solutions. The results showed that there exist hydrogen bonds
between 4-ASA and KGM, and the presence of KGM can cause the fluorescence quench in 4-ASA aqueous solution. The association constant of Ka is 77.32 L/mol, and the number of binding sites per sugar-ring is 0.94(R=0.991). The value 0.94 indicates1:1 complexation of the drug of 4-ASA with sugar-ring on the chain of
KGM. These results provide useful information for the practical application of these 4-ASA-polysaccharide systems in food and pharmaceutical industries.