Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles
作者：Zhong Luo, Kaiyong Cai, Yan Hu, Jinghua Li, Xingwei Ding, Beilu Zhang, Dawei Xu, Peng Liu
关键字：mesoporous silica
论文来源：期刊
具体来源：Advanced Materials, 2012, 24, 431–435
发表时间：2012年
A novel redox responsive controlleddrug release system based on magnetic nanoparticles for efficient intracellular anticancer drug delivery is fabricated. Disulfide bonds are employed as intermediate linkers to immobilize PEI/β-CD molecules as nanoreservoirs for drug loading onto magnetic nanoparticles. The endocytotic pathway and endosomal escape of the smart controlled drug release system is proposed.