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Journal of the American Chemical Society. 2002, 124, 14834-14835
作者:Lang, Meidong; Grzesiak, Adam L; and Matzger, Adam J
关键字:para-hydroxyacetanilide; orthorhombic form; paracetamol; acetaminophen; nucleation
论文来源:期刊
发表时间:2002年

A method for the production of crystalline polymorphs from solution is described which utilizes a diverse set of polymer heteronuclei. Application to crystalline polymorph selection for the important pharmaceuticals acetaminophen and carbamazepine is demonstrated. This method provides a new paradigm for polymorph selection, where solvent and temperature conditions can be chosen on the basis of process considerations and the polymer heteronucleus can be varied for specific polymorph production.