writer：Cuizhen Li, Chunhua Gu, Yan Zhang, Meidong Lang*
keywords：Poly (ε-caprolactone), Poly(acrylic acid), PH-responsive,
source：期刊
specific source：Synthesis and micellization of pH-responcive amphiphilic block copolymer Poly (ε-caprolactone)-block
Issue time：2012年

The pH-responsive amphiphilic PCL-b-PAA was synthesized via ATRP of Methoxymethlacrylate (MOMA), a hemiketal ester of acrylic acid, with PCL-Br as macroinitiator, and followed by the hydrolysis of PMOMA segment under a mild condition without the degradability of PCL segment. ¹H NMR, GPC,and FTIR were used to characterize the structure of polymers. Subsequently，the self-assembly of PCL-b-PAA was investigated by ?uorescence spectroscopy, DLS and TEM. The amphiphilic block copolymer formed the core-shell structural spherical micelles with 70 nm and the hydrodynamic radiusvaried with pH value and ionic strength. The MTT assay indicated that PCL-b-PAA was low toxic to fibroblast cells.