writer：Wenru Zhao, Hangrong Chen, Yongsheng Li, Liang Li, Meidong Lang, and Jianlin Shi
keywords：Uniform Rattle-type Hollow Magnetic Mesoporous Spheres, Drug Delivery Carriers, Sustained-Release
source：期刊
Issue time：2008年

A novel kind of rattle-type hollow magnetic mesoporous sphere (HMMS) with Fe3O4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol–gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H2 reduction. Such a structure has the merits of both enhanced drug-loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302mgg_1 when ibuprofen is used as a model drug, and the IBU–HMMS system has a sustained-release property, which follows a Fick’s law.