writer：Fangfang Chen, Weifeng Zhao, Jingjing Zhang, Jie Kong*
keywords：2D Molecularly Imprinted Materials, Recognition and Separation of Proteins, Magnetic
source：期刊
specific source：Phys. Chem. Chem. Phys., 2015, 2016, 18: 718 - 725 (Back Cover)
Issue time：2016年

Surface molecular imprinting for proteins is an emerging cross field of molecular imprinting engineering and functional materials. In this contribution, we report a novel design of magnetic two-dimensional molecularly imprinted polymers (2D-MIPs) for high recognition and separation of proteins. The bovine serum albumin-surface-imprinted polydopamines were prepared on the surfaces of magnetic Fe3O4–graphene oxide hybrid to form magnetic 2D-MIPs for proteins. The 2D Fe3O4–graphene oxide substrate possesses a dominant surface-to-volume ratio in comparison to 3D spherical substrate with the same volume. These materials are sensitive to a magnetic field and can be easily separated using an external magnet. The binding experiment results of bovine serum albumin on magnetic 2D-MIPs and real sample analysis demonstrated high recognition specificity, selectivity, accessibility and convenient separation of 2D-MIPs for template protein. The design and synthesis of magnetic 2D-MIPs provide a new perspective for the surface molecularly imprinted materials with potential in recognition and separation of proteins.

http://pubs.rsc.org/en/content/articlelanding/2014/CP/C5CP04218F#!divAbstract