相关链接
联系方式
  • 通信地址:山东第一医科大学化学与制药工程学院,科技创新中心,山东济南
  • 邮编:250021
  • 电话:18865922696
  • 传真:
  • Email:jiangrujian@sdfmu.edu.cn
当前位置:> 首页 > 论文著作 > 正文
【Applied Surface Science, IF=6.707】Enzyme-mimicking polymer brush-functionalized surface for combating biomaterial-associated infections
作者:Jiang R., Xin Z., Xu S., et al
关键字:Enzyme-mimicking polymer brush, Photografting polymerization, DNA cleavage Antibacterial surface, Biomimetic surface
论文来源:期刊
发表时间:2017年
Biomaterial-associated infections critically compromise the functionality and performance of the medical devices, and pose a serious threat to human healthcare. Recently, natural DNase enzyme has been recognized as a potent material to prevent bacterial adhesion and biofilm formation. However, the vulnerability of DNase dramatically limits its long-term performance in antibacterial applications. In this work, DNase-mimicking polymer brushes were constructed to mimic the DNA-cleavage activity as well as the macromolecular scaffold of the natural DNase. The bacteria repellent efficacy of DNase-mimicking polymer brush-functionalized surface was comparable to that of the DNase-functionalized surface. More importantly, due to their inherent stability, DNase-mimicking polymer brushes presented the much better performance in inhibiting bacterial biofilm development for prolonged periods of time, as compared to the natural DNase. The as-developed DNase-mimicking polymer brush-functionalized surface presents a promising approach to combat biomaterial-associated infections.