writer：Liu Z., Chen C., Jiang R., et al
keywords：Biofilm detachment, Shape memory materials, Antimicrobial, Composite materials
source：期刊
Issue time：2020年
Biofilms that are responsible for a variety of chronic infections and antibiotic resistance have drawn much attention worldwide. A new strategy for mechanically disrupting and removing biofilms by thermal-triggered shape memory polyurethanes (SMPU) film composited with zinc oxide nanoparticles (ZnO NPs) is reported here. Upon thermal triggered shape recovery, most of the adhered biofilm can be detached from the surface of the SMPU, while the incorporated ZnO NPs could efficiently eliminate the adhered initially and residual bacteria after detaching activity, without leaching of bactericidal species. Furthermore, the composite films exhibited low cytotoxicity to mammalian cells as revealed by cell viability tests. We envision that this antibacterial strategy may find unique applications in biomedical devices, especially for those biofilm-associated infections. (C) 2020 Elsevier B.V. All rights reserved.