writer：Jinqiang Jiang,? Xia Tong,? Denis Morris,? and Yue Zhao*,?
keywords：Toward Photocontrolled Release Using Light-Dissociable Block Copolymer Micelles
source：期刊
specific source：Macromolecules 2006, 39, 4633-4640
Issue time：2012年

Micellar aggregates (core-shell micelles, vesicles, etc.) formed by amphiphilic block copolymers (BCPs) are being actively investigated as a nanocarrier system for controlled delivery of drugs and other biological substances.1 Generally speaking, a good nanocarrier of drugs would be (1) stable during the circulation in the blood, allowing no release of encapsulatedhydrophobic drugs, (2) able to accumulate specifically in the target site (e.g., tumors), and (3) once on target, able to release the carried drug quickly or in a controlled fashion. Each of these requirements has prompted a great deal of research efforts in the design, synthesis and exploitation of new BCPs. As far as the control of release is concerned, BCP micelles that can be disrupted by external stimuli, thus triggering the release of entrapped agents, are of particular interest. The stimuli studied so far not only include changes that BCP micelles in the body can experience, such as increase or decrease in pH,2 intemperature3 and exposure to oxidation reaction,4 but also include sound5 and light6-8 that can be applied from outside of the body

for remote activation of the disruption of micelles.

https://pubs.acs.org/doi/pdf/10.1021/ma060142z