(Macromol. Rapid Commun)Amphiphilic Imbalance and Stabilization of Block Copolymer Micelles on-Demand through Combinational Photo-Cleavage and Photo-Crosslinking
writer：Xuan Zhang, Youpeng Wang, Guo Li, Zhaotie Liu, Zhongwen Liu, Jinqiang Jiang*
keywords：amphiphilic imbalance; micellar stability; photolysis; photo-crosslinking; polymer micelles
source：期刊
specific source：Macromol. Rapid Commun. 2017, , 1600543
Issue time：2017年
An amphiphilic block copolymer of poly(ethylene oxide)-b-poly((N-methacryloxy phthalimide)-
co-(7-(4-vinyl-benzyloxyl)-4-methylcoumarin)) (PEO45-b-P(MAPI36-co-VBC4)) is designed to
improve the micellar stability during the photo-triggered release of hydrophobic cargoes.
Analysis of absorption and emission spectra, solution transmittance, dynamic light scattering,and transmission electron microscopy supports that polymer micelles of PEO45-b-P(MAPI36-co-VBC4) upon the combinational irradiation of 365 and 254 nm light can be solubilized through the photolysis of phthalimide esters and simultaneously crosslinked via the partially reversible photo-dimerization of coumarins. The photo-triggered release experiment shows that the leakage of doxorubicin molecules from crosslinked micelles can be predictably regulated by controlling the irradiation time of 365 and 254 nm light.