writer：Yanning Liu, Guo Li, Jiangang Chen, Zhaotie Liu, Zhongwen Liu, Jinqiang Jiang*
keywords：iminoboronate ester; multi-component reaction; multi-sensitive; polymer nano-aggregates; synergistic release
source：期刊
specific source：Macromol. Rapid Commun. 2017, DOI: 10.1002/marc.201600805
Issue time：2017年

A triple-sensitive polymer of poly(ethylene glycol)-iminoboronate nitrobenzyl ethanediol

chelate (PEG-INEC) is efficiently fabricated via the convenient aqueous iminoboronate

multi-component reaction (MCR) of methoxypolyethylene glycol amine (mPEG-NH2), 2-formylphenylboronic acid (FPBA), and bis(2-nitrophenyl) ethanediol (BNPE, a photo-cleavable nitrobenzyl alcohol derivate). The aqueous MCR synthetic procedure is followed using 1H NMR and turbidity analysis. It is shown that polymer nano-aggregates of PEG-INEC in aqueous solution can be dissociated through the stimuli responsive reactions of the hydrophobic iminoboronate nitrobenzyl ethanediol chelates (INECs) when exposed to UV light, acid, and H2O2, respectively. Furthermore, upon the stimulation of combined triggers, the dissociation of polymer nano-aggregates can be accelerated to different extents, resulting in the synergistic release of encapsulated hydrophobic molecules in water. The proposed facile and general method is quite desirable and of great importance in practical applications like drug and gene delivery.