writer：Yunting Liu, Aidang Lu, Keling Hu, Youming Wang,* Haibin Song, Zhenghong Zhou,* and Chuchi Tang
keywords：Chiral Catalysis, Squaramide, Michael Addition
source：期刊
specific source：European Journal of Organic Chemistry
Issue time：2013年

A highly diasterero- and enantioselective intramolecular Michael addition of keto-enones has been realized. By using the (R,R)-1,2-diphenylethane-1,2-diamine-based bifunctional primary amine-squaramide catalyst, the reaction proceeded smoothly to generate the corresponding trans-2,3-disubstituted dihydrobenzofuran derivatives in excellent yields with good to excellent diastereo- and enantioselectivities (up to 97:3 dr, up to 99% ee).