writer：Zhang JT, Xue YN, Gao FZ, Huang SW*, Zhuo RX
keywords：Drug delivery, hydrogel
source：期刊
specific source：Journal of Applied Polymer Science, 2008, 108 (5), 3031-3037
Issue time：2008年

In this study, novel thermally sensitive semi-interpenetrating polymeric network hydrogels composed of poly(N-isopropylacrylamide) (PNIPAAm) and beta-cyclodextrin-grafted polyethylenimine were prepared by radical polymerization. Compared to normal PNIPAAm hydrogels, the semi-interpenetrating network hydrogels had a higher swelling ratio at room temperature and exhibited faster shrinking kinetics when the temperature was elevated to above the lower critical solution temperature. Propranolol as a model drug was loaded into the gels, and the release results show that compared to that of the normal PNIPAAm hydrogel, the release time of propranolol from the cyclodextrin-containing gel was prolonged. These improved drug-release properties may have been due to the formation of inclusion complexes between the drug molecules and cyclodextrin groups.