作者：Xiangxiang Du, Guohua Jiang*, Lei Li, Wentong Yang, Hua Chen, Yongkun Liu, Qin Huang
关键字：glucose-sensitive; fluorescence; photopolymerization; chemenzymatic tranesterification; drug release
论文来源：期刊
具体来源：Journal of Applied Polymer Science, 2016, 133(9), 43026
发表时间：2016年

Glucose-sensitive and fluorescence copolymer micelles were designed and prepared via combination of photoinitiated polymerization and enzymatic transesterification. The water-soluble photoinitiator and emulsifier 2-oxooctanoic acid (2-OOA) self-polymerized dimer molecules under UV irradiation characterized by mass spectrum (MS). The fluorescence dye, 9-anthracene alcohol (9-AMOH) and biocompatible hydrophilic chains, polyethylene glycol (PEG-OH), were introduced to the polymer chains during the photopolymerization and enzymatic transesterification process. The as-prepared copolymers were confirmed by 1H NMR、FT-IR、TEM and DLS. The resultant copolymers exhibited the excellent glucose sensitivity and stability against protein. The optical fluorescence properties of copolymer micelles were investigated using fluorescence spectrophotometer and fluorescence microscope and confocal laser scanning microscopy (CLSM). Due to the amphiphiilic feature, the micelles could be self-assembled and used to load insulin. The controlled release of insulin were evaluated triggered by glucose in vitro. This work provided a new strategy for fabricating functional carriers as self-regulated insulin release systems.