由硕士研究生毛亚楠等完成的研究论文"Fabrication of hollow microneedles with double-layer shell structure for rapid and prolonged local anesthesia?"被《Journal of Drug Delivery Science and Technology》录用！

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Abstract: Pain is a subjectivesensation associated with actual or potential tissue damage, presenting a global clinical challenge that not only significantly impactsindividuals’ quality of life, but also incurs substantial economic burdens. In this study, polymer microneedles (MNs) with hollow double-layer shell structure had beendesigned for local long-lasting analgesia.The hollow and inner-shell layer were formed by amicrotemplate method under vacuum and UV cross-linking.The formed cavities in MNs could be utilized for loadinglidocaine hydrochloride (LidH) powder to increase the drug loading capacity.The outer-shell layer formed a frozen dip-coating processwas composed of poly(vinylpyrrolidone) (PVP),citric acid (CA),sodium bicarbonate (NaHCO3), and small amount of LidH. After insertion into skin, the outermost shell of MNs could been rapidly dissolved, leading to a rapid release ofLidH to achieve a rapid analgesia. Subsequently, theLidH loadedwithin the cavitycould becontinuously released due to swelling of the inner shell, therebyto obtain long-term analgesic effect.In vivo local analgesic tests reveled that local analgesic time could be extended up to 48 h, showing apotential possibility toreduce administration frequency and improve patient comfort.

Keywords: microneedles; transdermal administration; local analgesia; drug delivery