writer：Guohua Jiang*, Tengteng Jiang, Xia Li, Zhen Wei, Xiangxiang Du, Xiaohong Wang
keywords：carbon quantum dots, glucose determination, fluorescent probe
source：期刊
specific source：Materials Research Express
Issue time：2014年
 

The nitrogen doped carbon quantum dots (NCQDs) with about 10 nm in diameter have been obtained by hydrothermal reaction from collagen. Because of the superiority of water dispersion, low toxicity and ease to functionlization, the NCQDs were designed as a glucose sensor after covalent grafting by APBA (APBA-NCQDs). The as-prepared APBA-NCQDs were imparted with glucose sensitivity and selectivity from other saccharides via fluorescence (FL) quenching effect at physiological pH and at room temperature, which show high sensitivity and specificity for glucose determination with a wide range from 1 mM to 14 mM. FL quenching mechanism of APBA-NCQDs was also investigated by adding an external quencher. The APBA-NCQDs-based platform is an environmentally friendly way to substitute inorganic quantum dots containing heavy metals which offer a facile and low cost detection method.