writer：Junhao Zhang, Yanfang Sun, Luping Ren, Lianxu Chen, Lei Nie, Admin Shavandi, Khaydar E. Yunusov, Ul
keywords：Red blood membrane; dopamine; tubercidin; chemodynamic therapy; photothermal therapy; synergistic therapy
source：期刊
specific source：ACS Biomaterials Science and Engineering
Issue time：2023年

Abstract: Combinations of different therapeutic strategies, including chemotherapy (CT), chemodynamic therapy (CDT), and photothermal therapy (PTT), are needed to effectively address evolving drug resistance and the adverse effects of traditional cancer treatment. Herein, a camouflage composite nanoformulation (TCBG@PRs), an antitumour agent (tubercidin, Tub) loaded into Cu-doped bioactive glasses (CBGs) and subsequently camouflaged by polydopamine (PDA) and red blood cell membranes (RBCm), was successfully constructed for targeted and synergetic antitumour therapies by combining CT of Tub, CDT of doped copper ions, and PTT of PDA. In addition, the TCBG@PR composite nanoformulation was camouflaged with a red blood cell membrane (RBCm) to improve biocompatibility, longer blood retention times, and excellent cellular uptake properties. It integrated with long circulation and multimodal synergistic treatment (CT, CDT, and PTT) with the benefit of RBCms to avoid immune clearance for efficient targeted delivery to tumor locations, producing an "all in one" nanoplatform. In vivo results showed that the TCBG@PR composite nanoformulation prolonged blood circulation and improved tumor accumulation. The combination of CT, CDT, and PTT therapies enhanced antitumour therapeutic activity, and light-triggered drug release reduced systematic toxicity and increases synergistic antitumor effects.