writer：Tianqi Liu, Yanfang Sun*, Guohua Jiang *, et al
keywords：Microneedle patches; transdermal delivery; wound healing; blood glucose levels; tissue Regeneration; skin adhesion
source：期刊
specific source：Acta Biomaterialia
Issue time：2023年

Abstract: Diabetes chronic wound is a serve and frequently occurring medical issues in patients with diabetes that often lead to more serious complications. Microneedles (MNs) can be used for wound healing due to their ability to effectively pierce the epidermis and deliver drugs into the wound tissue. However, common MNs patches cannot provide sufficient skin adhesion to prevent them from the detachment at the wound area. Herein, inspired by barb hangnail microstructure of porcupine quills, we designed a porcupine quill-like multilayer MNs patch with an adhesive back patching for tissue adhesion and diabetic wound healing. Sodium hyaluronate-modified CaO2 nanoparticles (CaO2-HA NPs) and metformin (hypoglycemic agent) were loaded into the polycaprolactone (PCL) tips of MNs, endowing them with exceptional antibacterial ability and hypoglycemic effect. The flexible and adhesive back patching was formed by polyacrylamide-polydopamine/Cu2+ (PPC) composite hydrogel which ensure the MNs patches could not been fall off from the application sites and reduce bacterial infection. The bio-inspired multilayer structure MNs patches exhibit satisfactory mechanical and antibacterial properties, which is a potential multifunctional dressing platform for promoting wound healing.

Keywords: Microneedle patches; transdermal delivery; wound healing; blood glucose levels; tissue Regeneration; skin adhesion