writer：Xue-ya Zhang, Guo-hua Jiang*, Gao Song, Tian-qi Liu, Yan-fang Sun*, Zhi-yong Zeng
keywords：Nanocarriers, biomaterials, chemical therapy, chemo-dynamic therapy, photothermal therapy
source：期刊
specific source：Frontiers of Materials Science
Issue time：2021年

By in-situ growth of MnO₂ on solid SiO₂ nanoparticles (NPs) and then removal of SiO2 nuclei, highly dispersed hollow manganese dioxide (h-MnO₂) with uniform morphology can be obtained. The obtained h-MnO₂ is further used to load anticancer drug doxorubicin (DOX) and subsequently modified with biocompatible and biodegradable polydopamine (PDA), finally to form polydopamine-coated DOX/h-MnO₂ nanocomposites (DOX/h-MnO₂@PDA). Due to the photothermal of PDA, photodynamic performance of the h-MnO₂, and chemical therapy effect of DOX, the obtained DOX/h-MnO₂@PDA can be used to inhibit tumor cells via a photo-chemical synergetic therapy method.