writer：Song, Gao; Jiang, Guohua; Liu, Tianqi; Zhang, Xueya ; Zeng, Zhiyong ; Wang, Ruofan ; Li, Pengfei; Ya
keywords：microneedles, superficial skin tumors, photothermal?therapy, chemotherapy, synergistic effect
source：期刊
specific source：ACS Biomaterials Science & Engineering
Issue time：2020年

Abstract: It is extremely important to develop a minimally-invasive and efficient approach for treatment of superficial skin tumors (SST). In this work, a near-infrared (NIR)-triggered transdermal therapeutic system based on two-stage separable microneedles (MNs) has been proposed for synergistic chemo-photothermal therapy against SST. Lauric acid and polycaprolactone (LA/PCL) with phase change property have been used to prepare the arrowheads of the two-stage separable MNs in which embedded anticancer drug (doxorubicin, DOX) and photothermal agent (indocyanine green, ICG). The arrowheads are capped on the dissolvable poly(vinyl alcohol)/polyvinyl pyrrolidone (PVA/PVP) support bases. After inserting into skin tissue, the PVA/PVP support bases can be dissolved quickly owing to the absorption of the interstitial fluid, leading the arrowheads to be left in the skin tissue. Under the NIR irradiation, the arrowheads embedded in the skin can be ablated due to the photothermal conversion of the ICG, resulting in liberation and penetration of the DOX from the MNs into tumor tissue. The mouse model of melanoma tumor has been established to evaluate the synergistic effect of two-stage separable microneedle phototherapy and chemotherapy in the treatment of skin cancer.