writer：Min Sang Kim, Guang Hui Gao, Seong Woo Kang, Doo Sung Lee
keywords：Protein delivery
source：期刊
specific source：Macromol. Biosci.
Issue time：2011年

In this study, some possible biomedical applications of a pH-sensitive and amphiphilic

copolymer as a pH sensor and protein delivery system are reported. PAE-g-PEG was used

as a pH-sensitive polymer that can exhibit a sharp pH-dependent transition. Various fluore-

scent dyes including pyrene and RITC can be used to label the pH-sensitive polymer PAE-g-PEG,

which was evaluated for protein encapsulation. pH-sensing was possible by observing

excimer formation of the labeled pyrene via pH-dependent expansion of the polymeric

chain. Also, it was confirmed that FITC-BSA could be entrapped in RITC-labeled pH-sensi-

tive micelles of PAE-g-PEG by FRET. As a result,

PAE-g-PEG can be a pH sensor and carrier for

protein delivery.