[Macromol. Rapid Commun.] Microwave-Assisted Synthesis of GlycopolymerFunctionalized Silver Nanoclusters: Combining the Bioactivity of Sugar with the Fluorescence and Cytotoxicity of Silver
writer：Wei Lu, Wenjuan Ma, Jiawei Lu, Xiao Li, Yun Zhao, Gaojian Chen
keywords：http://onlinelibrary.wiley.com/doi/10.1002/marc.201300905/abstract
source：期刊
specific source：Macromol. Rapid Commun., 2014, 35: 827–833.
Issue time：2014年
Copolymers of
2-(methacrylamido)glucopyranose (MAG) and methacrylic acid (MAA) are
synthesized by RAFT polymerization and then used as templates to prepare
glycopolymer-functionalized Ag nanoclusters (Gly-Ag NCs) through
microwave irradiation. Polymers and the resulting nanoclusters are
characterized by NMR, GPC, UV-Vis, SEM, TEM, AAS and fluorescence
spectroscopy. The bio-activity of the fluorescent Gly-Ag NCs are further
examined using GLUT-1 over-expressing cancer cells K562. Gly-Ag NCs
show efficient binding ability toward K562 cells and inhibit the cell
viability in a dose dependent manner (IC50 = 0.65 μg mL(-1) ),
indicating their potential biological applications for both cancer
imaging and targeted cancer therapy.
