writer：Gaolai Du, Lei Nie, Guorong Gao, Yuanna Sun, Ruixia Hou, Hua Zhang, Tao Chen, and Jun Fu*
keywords：hydrogel, PVA, graphene oxide, di-thiol
source：期刊
specific source：ACS Applied Materials and Interfaces, 2005, 7, 3003-3008.
Issue time：2015年

Interpenetrating network (IPN) strategy has been widely facilitated to construct strong and tough hydrogels, but most of the effects are focused on organic/organic parents. Herein, aqueous dispersible 2, 2’-(ethylenedioxy)-diethanethiol (EDDET) crosslinked graphene oxide (E-cGO) skeleton was in situ incorporated into PVA matrix, resulting in novel inorganic/organic IPN hydrogels with super mechanical and chondrocyte cell-adhesion properties. The unique interpenetrating structure and hydrogen bonding were demonstrated to play critical roles in enhancing the compressive property of the IPN hydrogels, in comparison to the GO and thermally reduced graphene oxide (T-rGO) filled hydrogels. It is critical that the E-cGO/PVA hydrogels have been demonstrated biocompatible, which provided the E-cGO/PVA hydrogels as promising candidate biomaterials for load-bearing bio-tissue substitution.