writer：1. Chao Fang, Ruixia Hou, Kefeng Zhou, Feibin Hua, Yang Cong, Jianfeng Zhang, Jun Fu* and Yajun Chen
keywords：Bone cement, BaSO4 nanopraticles
source：期刊
specific source：J Mater Chem B, 2013, DOI: 10.1039/C3TB21544J.
Issue time：2014年
The controlled synthesis of surface functionalized BaSO4 nanoparticles with the diameter below 50 nm is achieved by combining the in situ generation of SO42- and the use of difunctional surface modification agent of (2-(Methacryloyloxy) ethyl dimethyl-(3-sulfopropyl) ammonium hydroxide (MSAH). Particularly, a pre-decomposition process of the SO42- precursor (S2O82-) is applied to decouple the in situ generation of SO42- and precipitation of BaSO4. As a result, the nucleation and growth of BaSO4 particles is manipulated, which significantly reduces the particle size. Different combinations of the pre-decomposition time and MSAH/BaCl2 molar ratios showed remarkable influence on the morphology and surface functionality of the BaSO4 particles. Furthermore, the morphology control by using other difunctional surface modification agents is examined. The MSAH-functionalized BaSO4 nanoparticles used as filler in bone cements effectively improved the bending modulus and compressive strength of the PMMA bone cements. The bone cement with MSAH-functionalized BaSO4 nanoparticles exhibited good radiopacity. Moreover, in vitro cell culture experiments demonstrated improved biocompatibility compared to bare BaSO4 particles. The MSAH-functionalized BaSO4 nanoparticles may be ideal candidate material as bone cement filler.