writer：Cheng-Guang Mu, Xiao-Dong Fan, Wei Tian, Yang Bai, Zhen Yang, Hao Yao, Heng Chen
keywords：cyclodextrin, N-isopropylacrylamide, micelles, nonlinear polymers, self-assembly, synthesis
source：期刊
specific source：Journal of Polymer Science Part A: Polymer Chemistry Volume 51, Issue 6, pages 1405–1416, 15 March 2
Issue time：2013年
We report on the synthesis of an H-shaped polymer bondingb-cyclodextrin (b-CD) at branch points and influences of attachedb-CD on physical properties. First, a poly(ethyleneglycol)(PEG)-based functional macroinitiator bearing two azidos and four chlorines at chain-ends (PEG-2N3(-4Cl)) was prepared via terminal modification reactions. Then, PEG-2N3(-4Cl) was applied to initiate the atom transfer radical polymerization of N-isopropylacrylamide, leading to the synthesis of an Hshaped block polymer with PEG as the central chain and poly(N-isopropylacrylamide) (PNIPAM) as side-arms (PEG-2N3(-4PNIPAM)). Azido groups were at the branch points of the
polymer. Finally, the click reaction between PEG-2N3(-4PNIPAM) and alkynyl monosubstituted b-cyclodextrin (b-CD) afforded another H-shaped polymer with twob-CDs bonding at the polymer branch points (PEG-2CD(-4PNIPAM)). The glass transition temperature (Tg) and lower critical solution temperature (LCST) of the H-shaped polymer increased after the attachment of b-CD. The self-assembly and thermal responsive behaviors, as well as the encapsulation behaviors
of PEG-2CD(-4PNIPAM) were also altered. When temperature was below the LCSTs, PEG-2N3(-2PNIPAM) dissolved in water molecularly, whereas PEG-2CD(-4PNIPAM) could selfassemble into nano-sized micelles. After the LCST transitions, PEG-2N3(-4PNIPAM) aggregated into micron-sized unstable particles, whereas PEG-2CD(-4PNIPAM) transformed into PNIPAM-cored nanomicelles. Besides, PEG-2CD(-4PNIPAM) can

encapsulate doxorubicin below its LCST due to the formation of micelles.

全文链接：http://onlinelibrary.wiley.com/doi/10.1002/pola.26512/full