writer：Du, J. Z.; Armes, S. P.
keywords：polymer vesicles, self-assembly
source：期刊
specific source：J. Am. Chem. Soc., 2005, 127 (37), pp 12800–12801
Issue time：2005年

A new type of shape-persistent, pH-responsive vesicle was prepared by the self-assembly of a novel poly(ethylene oxide)-block-poly[2-(diethylamino)ethyl methacrylate-stat-3-(trimethoxysilyl)propyl methacrylate], PEO-b-P(DEA-stat-TMSPMA), copolymer. Vesicles were formed spontaneously in aqueous THF solution, with the hydrophilic PEO chains forming the corona and the pH-sensitive P(DEA-stat-TMSPMA) blocks being located in the membrane walls. Hydrolytic cross-linking within the hydrophobic membrane walls fixed the vesicle morphology. The resulting colloidally stable vesicles were characterized by ¹H NMR, transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and stopped-flow fluorescence experiments. The latter technique indicated that the permeability of the vesicle walls was sensitive to the pH of the aqueous solution, as expected. Gold-decorated vesicles were obtained by in situ reduction of AuCl₄^- anions to produce gold nanoparticles within the vesicle walls. (Yellow, hydrophilic PEO; green, pH-responsive DEA residues; blue, hydrolytically self-cross-linkable TMSPMA residues.)

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