writer：Zhang, X; Xu, HP; Dong, ZY; et al.
keywords：Organoselenium Compounds, Dendrimers, Glutathione Peroxidase, Catalysis
source：期刊
Issue time：2004年
In this communication, we report the synthesis of the three generations of Fréchet-type poly(aryl ether) dendrimers with a diselenide core that demonstrate generation-dependent glutathione peroxidase (GPx) activity with initial reduction rates as high as 2431.20 μM min^-1 for the third-generation product, around 1400 times faster than Ebselen. It represents a successful example of using a dendrimer as a model for a GPx mimic.