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Calcium-dependent and -independent annexin V binding: distinct molecular behaviours at cell membrane interfaces
writer:Yong-Hao Ma, Bolin Li, Jingjing Yang, Xiaofeng Han, Zhan Chen* and Xiaolin Lu*
keywords:annexin V binding, molecular behaviours, SFG, calcium
source:期刊
specific source:Chem. Commun., 2020, 56, 1653
Issue time:2020年

Distinct annexin V binding behaviours in Ca2+-dependent and Ca2+-independent cases were comparatively investigated using sum frequency generation vibrational spectroscopy. It was discovered that binding affected the molecular arrangement of both membrane leaflets, and the initial Ca2+-independent binding went through a transition with annexin V reorientation to a more stable state upon adding Ca2+.

https://pubs.rsc.org/en/content/articlelanding/2020/cc/c9cc09184j#!divAbstract