1.医用材料表面工程化;
采用层层自组装技术,在生物材料表面构建具有多功能、多响应型的纳米涂层,实现植入性纳米材料的防止炎症感染,促进组织愈合以及生物相容性。
实例1:多功能纳米载药涂层的构建
Fig.2. Tunable drug loading and releasing from anti-infection peptide nanocoatings. (a) Nanoassembly with nano-scale structure; (b) Controllable antibiotic incorporation; (c) Tunable releasing of antibiotics; (d) Anti-bacterial activity with Kirby-Bauer assays.
实例2:具有仿生结构的生物涂层的构建
Fig.4. SEM images showed cell adhesion behaviors on ECM-like nanocoating surface. (a)—(c) were the osteoblast adeshision on peptide nanocoating with/without ECM-like structure. (d) was fibroblast adhesion on the same coating as that in (c).
2. 纳米给药;
可生物相容、降解的离子高分子分子设计、合成、药物载体的组装行为及其定向传递.
实例1:纳米粒子的细胞定向传递
Fig.5 Particle size, zeta potential and morphology and cell cytotoxicity of PEI-grafted PLGA nanoparticles and the surface-modified nanoparticles
Fig.5 Association of surface-modified nanoparticles with osteoblast cells and their intracellular delivery into cell. The nanoparticles in square areas are immobilized into osteoblast cells. A double-stained method was used to indentify the intracellular location of nanoparticles.
3. 温室气体吸附材料
新型CO2吸附材料的分子设计、合成及其液相、固相吸附剂的合成与性能;CO2的吸附与光催化转化反应器的设计与制备。
实例1. 基于层层自组装技术的纳米层状吸附剂
Fig.6 Nanolayered solid sorbents for CO2 capture based on LBL technology
Fig.7 Rapid kinetics(top left) and highly-ordered structure (below left) of nanolayered sorbent and its high amine-efficiency for CO2 capture