作者：Bai, Y.,* Liu, C.P., Song, X., Zhuo, L.H., Bu, H.T., Tian, W.*
关键字：cyclodextrins， drug delivery，host–guest systems ， self-assembly， supramolecular chemistry
论文来源：期刊
具体来源：Chemistry-an Asian Journal. 2018, 13, 3903-3911
发表时间：2018年

Despite the progress has been made in the application

of supramolecular prodrug self-assemblies to enhance the functionality of drug

delivery systems, the corresponding research on multiple responsive

supramolecular prodrug self-assemblies for programmed drug delivery is still

limited. In this paper, the synthesis and self-assembly behaviours of

supramolecular prodrug complexes (SPCs) with β-cyclodextrin-acylhydrazone-DOX and the

targeting of azobenzene-terminated poly(2-(dimethylamino)ethyl methacrylate)

(Azo-PDMA-FA) as building blocks are investigated and

described. The obtained SPCs can further form self-assemblies based on their

amphiphilic nature. Next, SPCs-based multi-compartment vesicles and complex micelles,

which are confirmed by transmission electron microscopy (TEM) and

dynamic/static light scattering (DLS/SLS), are obtained with good reversibility

under alternative visible light or UV irradiation. Furthermore, three-stage

programmed drug delivery behaviour was observed from dually responsive SPCs-based

self-assemblies utilizing UV and pH stimuli. Specifically, SPCs first

self-assembled into multi-compartment vesicles accompanied by a slow release of

DOX. Next, UV light irradiation induced the dissociation of β-CD/Azo, leading to the morphology transition and slightly enhanced release of DOX. When the self-assemblies were

transferred to PBS solution (pH 5.0), the release rates increased notably due

to the broken acylhydrazone bond. Finally, basic cell experiments further

demonstrated that the SPCs-based self-assemblies could be internalized into

cancer cells, suggesting their promise for applications in cancer therapy.