首页
最新动态 交流合作 科研项目 论文著作 精彩瞬间 招生招聘
  • κ-Carrageenan and hyaluronic acid composite injectable hydrogel-containing isosorbide mononitrate-loaded liposomes for treatment of myocardial?infarction
  • 来源:江国华教授个人网站 2025-06-04
  • Abstract: In this study, isosorbide mononitrate (ISMN)-loaded liposomes (ISMN-LNPs) were encapsulated within an injectable composite hydrogel that consisted of κ-Carrageenan (κ-Car), hyaluronic acid (HA), and tannic acid (TA). The fabricated composite hydrogel exhibited exceptional reactive oxygen species (ROS) scavenging capabilities to enhance cell migration. Upon injection of the ISMN-LNP-loaded composite hydrogel into the injured hearts of rats, significant improvements in cardiac function could be observed after treatment. Furthermore, Masson’s staining results revealed that the injectable hydrogel system reduced myocardial infarct size and increased left ventricular wall thickness post-myocardial infarction. Immunofluorescence staining results indicated the upregulating expression of vascular hemophilic factor (VWF) and α-actinin, suggesting that the injectable hydrogel system to promote vascular proliferation and enhance cardiac systolic and diastolic function following myocardial infarction.

    Keywords: injectable hydrogel, myocardial infarction, liposomes

  • [来源:中国聚合物网]
  • 了解更多请进入: 江国华教授个人网站
相关新闻
  • · Review on engineered polymer microneedles for drug delivery and disease diagnosis
  • · Platelet membrane-camouflaged bioactive glass nano-formulations for enhanced drug delivery in the treatment of acute arterial thrombosis
  • · Hydrogel microneedles with multifunctional strategy for prolonged hyperuricemia management
  • · Iontophoresis-driven transdermal drug delivery system based on porous microneedles for hyperuricemia treatment.

关于我们  |  联系我们  

网站:中国聚合物网

polymer.cn Copyright ©2017