Abstract: Pressure sensors with linear high sensitivity and a broad response range enable the capture of subtle pressure changes across various scenarios, making them essential for accurate detection. Conventional methods typically employ porous and layered designs to boost sensitivity but they can compromise stability due to mechanical mismatches and interface incompatibilities between diverse materials. To address these issues, we propose a homogeneous interfacial locking strategy that simultaneously improves the linear response range and stability of the sensor. This approach uses aqueous polyurethane (WPU) as the interface-locking material, which matches the material properties of the substrate polyurethane (PU) sponge. This compatibility anchors the deposited MXene nanosheets to the sponge framework, establishing a robust mechanical and electrical interface. Additionally, the partial filling of the sponge’s pores with WPU enhances its mechanical compressibility. As a result, the sensor achieves high sensitivity (6226 kPa?1), a wide detection range (up to 146 kPa) and excellent durability (over 100,000 cycles), making it suitable for long-term human posture monitoring and analysis. This strategy offers a promising pathway for developing pressure sensors with high sensing performance and improved stability.