A new class of thermoplastic polyamide elastomers was successfully synthesized by polyaddition reactions between amino-terminated polyamide-6 and different diisocyanate-terminated polyether diols or polyester diols in a Haake torque rheometer. The chemical structure, phase separation, static and dynamic mechanical properties, thermal stability and hydrophilicity of TPAEs were characterized by Fourier transform infrared spectroscopy, differential scanning calorimeter (DSC), tensile tests and dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA), and water contact angle test methods, in the order given. DSC results showed that these synthesized TPAEs exhibited two obvious endothermic peaks associated with melting transition of soft segments and hard segments. The mechanical results revealed that TPAEs possess outstanding mechanical properties with tensile strength of 22.2– 35.9 MPa and the elongation-at-break of 360–467 %. TGA results showed TPAEs can be fabricated by traditional thermoplastic processing method without any decomposition once the processing temperature is below 300 °C. Furthermore, the TPAEs only dissolved in acetic acid and methanoic acid at room temperature, showing TPAEs can be applied to some harsh environment due to excellent organic solvent resistance. Especially, this friendly reactive processing can also be used to handle the environmental problems associated with volatile organic compound emission.