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  • Methoxy Poly(ethylene glycol)-b-Poly(L-lactic acid) Copolymer Nanoparticles as Delivery Vehicles for Paclitaxel
  • 来源:邓联东副教授个人网站 2009-09-10
  • Methoxy poly(ethylene glycol)-b-poly(l-lactic
    acid) (MPELLA) was prepared by the melt polycondensation
    of methoxy poly(ethylene glycol) and l-lactic acid.
    The structure and properties of MPELLA were characterized
    by IR, 1H-NMR, differential scanning calorimetry, and wideangle
    X-ray diffraction. To estimate its feasibility as a vehicle
    for paclitaxel, MPELLA nanoparticles were prepared by a
    self-emulsification/solvent evaporation method. The paclitaxel-
    loaded nanoparticles (PMTs) showed a spherical morphology
    with an inner core and an outer shell. The size, size distribution, and loading capacity of PMTs were also measured.
    The release kinetics of paclitaxel from PMTs in vitro
    was studied. The results show that paclitaxel can be effectively
    incorporated into MPELLA nanoparticles, which provide
    a delivery system for paclitaxel and other hydrophobic
    or toxic compounds.

  • [来源:中国聚合物网]
  • 了解更多请进入: 邓联东副教授个人网站
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