首页
最新动态 交流合作 科研项目 论文著作 精彩瞬间 招生招聘
  • 刘琳和于欢工作发表在Nature Communications
  • 来源:石恒冲研究员个人网站 2023-12-14
  • 该研究成果受到国家自然科学基金委网站报道,https://www.nsfc.gov.cn/publish/portal0/tab448/info92200.htm

    Abstract: Bacteria-associated infections and thrombosis, particularly catheter-related bloodstream infections and catheter-related thrombosis, are life-threatening complications. Herein, we utilize a concise assembly of heparin sodium with organosilicon quaternary ammonium surfactant to fabricate a multifunctional coating complex. In contrast to conventional one-time coatings, the complex attaches to medical devices with arbitrary shapes and compositions through a facile dipping process and further forms robust coatings to treat catheter-related bloodstream infections and thrombosis simultaneously. Through their robustness and adaptively dissociation, coatings not only exhibit good stability under extreme conditions but also significantly reduce thrombus adhesion by 60%, and shows broad-spectrum antibacterial activity (?>?97%) in vitro and in vivo. Furthermore, an ex vivo rabbit model verifies that the coated catheter has the potential to prevent catheter-related bacteremia during implantation. This substrate-independent and portable long-lasting multifunctional coating can be employed to meet the increasing clinical demands for combating catheter-related bloodstream infections and thrombosis.


  • [来源:中国聚合物网]
  • 了解更多请进入: 石恒冲研究员个人网站
相关新闻
  • · 房志月工作被Advanced Functional Materials接收!
  • · 张桢焱和王晓丹工作以VIP形式发表在Angew Chem Int Ed
  • · 张桢焱工作发表在Small
  • · 于欢关于抗菌泌尿类导管工作发表在Advanced Healthcare Materials

关于我们  |  联系我们  

网站:中国聚合物网

polymer.cn Copyright ©2017